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Gorgian Mohammadi, Masumeh, Bamdad, Taravat, Parsania, Masoud, Hashemi, Hamid Reza, Puyanfard, Somayeh. (1387). Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity. سامانه مدیریت نشریات علمی, 6(1), 22-27. doi: 10.22034/iji.2009.17069
Masumeh Gorgian Mohammadi; Taravat Bamdad; Masoud Parsania; Hamid Reza Hashemi; Somayeh Puyanfard. "Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity". سامانه مدیریت نشریات علمی, 6, 1, 1387, 22-27. doi: 10.22034/iji.2009.17069
Gorgian Mohammadi, Masumeh, Bamdad, Taravat, Parsania, Masoud, Hashemi, Hamid Reza, Puyanfard, Somayeh. (1387). 'Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity', سامانه مدیریت نشریات علمی, 6(1), pp. 22-27. doi: 10.22034/iji.2009.17069
Gorgian Mohammadi, Masumeh, Bamdad, Taravat, Parsania, Masoud, Hashemi, Hamid Reza, Puyanfard, Somayeh. Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity. سامانه مدیریت نشریات علمی, 1387; 6(1): 22-27. doi: 10.22034/iji.2009.17069

Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity

Iranian Journal of Immunology
مقاله 3، دوره 6، شماره 1، خرداد 2009، صفحه 22-27    اصل مقاله (204.77 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2009.17069
نویسندگان
Masumeh Gorgian Mohammadi1؛ Taravat Bamdad* 1؛ Masoud Parsania2؛ Hamid Reza Hashemi1؛ Somayeh Puyanfard1
1Department of Virology, School of Medical Sciences, Tarbiat Modares University
2Tehran Medical Unit, Islamic Azad University, Tehran, Iran
چکیده
Background: Herpes simplex virus type 1 is one of the most common viruses among human population. Studies demonstrate the essential role of cell mediated immunity, especially CD8+ T cells, in prevention and clearance of HSV1.
Objective: It is of great importance to improve our knowledge about the kinetics of CTL responses to primary and secondary HSV-1 infection.
Methods: Using a sensitive technique for detection and analysis of CD8+ T cells, granzyme B ELISA, the CTL activity in the spleens of Balb/c mice at various time points after intraperitoneal administration of HSV1 (strain KOS) in primary and secondary infections were determined.
Results: During acute HSV-1 infection, virus specific cytotoxic T cells were detected at day 5 post virus inoculation and peaked at day 7. Six hours after secondary infection the activity of memory CD8+ T cells was detected and peaked at 12 hours post infection.
Conclusion: The peak of CTL activity was found to be day 7 post infection in primary HSV-1 infections which decreased with time. In secondary infections, the activity of CTLs reached the highest level at 12 hours post infection.
کلیدواژه‌ها
HSV-1؛ CTL؛ Granzyme B
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