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Mishra, Mahendra Narain, Singai, Vinay. (1389). Human Leukocyte Antigen B27 in 453 Asian Indian Patients with Seronegative Spondyloarthropathy. سامانه مدیریت نشریات علمی, 7(4), 252-256. doi: 10.22034/iji.2010.17066
Mahendra Narain Mishra; Vinay Singai. "Human Leukocyte Antigen B27 in 453 Asian Indian Patients with Seronegative Spondyloarthropathy". سامانه مدیریت نشریات علمی, 7, 4, 1389, 252-256. doi: 10.22034/iji.2010.17066
Mishra, Mahendra Narain, Singai, Vinay. (1389). 'Human Leukocyte Antigen B27 in 453 Asian Indian Patients with Seronegative Spondyloarthropathy', سامانه مدیریت نشریات علمی, 7(4), pp. 252-256. doi: 10.22034/iji.2010.17066
Mishra, Mahendra Narain, Singai, Vinay. Human Leukocyte Antigen B27 in 453 Asian Indian Patients with Seronegative Spondyloarthropathy. سامانه مدیریت نشریات علمی, 1389; 7(4): 252-256. doi: 10.22034/iji.2010.17066

Human Leukocyte Antigen B27 in 453 Asian Indian Patients with Seronegative Spondyloarthropathy

Iranian Journal of Immunology
مقاله 8، دوره 7، شماره 4، اسفند 2010، صفحه 252-256    اصل مقاله (43.2 K)
نوع مقاله: Short Paper
شناسه دیجیتال (DOI): 10.22034/iji.2010.17066
نویسندگان
Mahendra Narain Mishra* 1؛ Vinay Singai2
1Department of Pathology, Command Hospital (SC)
2Department of Internal Medicine and Rheumatology, Command Hospital (SC), Pune, INDIA
چکیده
Background: Spondyloarthropathies are a group of closely related inflammatory arthritis which involve the axial skeleton and are negative for rheumatoid factor.
Objective: This case-control study was conducted to examine HLA- B27 positivity in patients with seronegative spondyloarthritis (SSA) as per ESSG criteria and compare the frequency with healthy controls because a lower positivity is reported in Indians.
Method: The study included 453 patients and 200 controls. HLA -B27 typing was done by microlymphocytoxicity and/or by sequence specific primers (SSP) using commercial kits. Patients were categorised as Ankylosing Spondylitis (AS), Undifferentiated Spondyloarthropathy, SSA with inflammatory bowel disease, reactive arthritis, psoriatic arthritis and juvenile spondyloarthropathy.
Results: HLA-B27 antigen was present in 56% of patient and 3.5% controls with highest frequency in juvenile spondyloarthropathy (80%), followed by AS (76%). The P value < 0.001 for all categories of SSA and overall Odds ratio was 34.9.
Conclusion: This study showed HLA-B27 frequency slightly lower than reported in Caucasian SSA patients and in our opinion HLA- B27 testing is extremely useful in young patients with suspected SSA.
کلیدواژه‌ها
HLA- B27؛ Spondylarthropathies؛ Asian Continental Ancestry Group
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