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Hussain, Shahid, Afzal, Nadeem, Javaid, Khursheed, Ullah, Muhammad Ikram, Ahmad, Tanveer, -Zaman, Saleem-Uz. (1389). Level of Interferon Gamma in the Blood of Tuberculosis Patients. سامانه مدیریت نشریات علمی, 7(4), 240-246.
Shahid Hussain; Nadeem Afzal; Khursheed Javaid; Muhammad Ikram Ullah; Tanveer Ahmad; Saleem-Uz -Zaman. "Level of Interferon Gamma in the Blood of Tuberculosis Patients". سامانه مدیریت نشریات علمی, 7, 4, 1389, 240-246.
Hussain, Shahid, Afzal, Nadeem, Javaid, Khursheed, Ullah, Muhammad Ikram, Ahmad, Tanveer, -Zaman, Saleem-Uz. (1389). 'Level of Interferon Gamma in the Blood of Tuberculosis Patients', سامانه مدیریت نشریات علمی, 7(4), pp. 240-246.
Hussain, Shahid, Afzal, Nadeem, Javaid, Khursheed, Ullah, Muhammad Ikram, Ahmad, Tanveer, -Zaman, Saleem-Uz. Level of Interferon Gamma in the Blood of Tuberculosis Patients. سامانه مدیریت نشریات علمی, 1389; 7(4): 240-246.

Level of Interferon Gamma in the Blood of Tuberculosis Patients

Iranian Journal of Immunology
مقاله 6، دوره 7، شماره 4، اسفند 2010، صفحه 240-246    اصل مقاله (921.02 K)
نوع مقاله: Original Article
نویسندگان
Shahid Hussain1؛ Nadeem Afzal* 2؛ Khursheed Javaid2؛ Muhammad Ikram Ullah3؛ Tanveer Ahmad4؛ Saleem-Uz -Zaman5
1Department of Physiology and Cell Biology
2Department of Immunology
3Biochemistry department
4Histopathology department, University of Health Sciences, Lahore, Pakistan
5Department of Pulmonary Medicine,Shalamar Hospital, Lahore, Pakistan
چکیده
Background: Interferon gamma (IFN-γ), a cytokine produced by a variety of cells is involved in the immune response against M. tuberculosis. It activates the production of other cytokines and molecules that kill mycobacterium. IFN-γ also has diagnostic role in identification of active and latent tuberculosis.
Objective: To determine the level of IFN-γ in the blood of TB patients.
Methods: Ninety-one subjects were selected, including 54 active TB patients and 37 healthy controls. Among 54 TB patients, 27 had confirmed TB and 27 were clinically diagnosed as having TB. IFN-γ concentration was determined in their blood by an ELISA technique.
Results: In TB patients, Mean + SD of IFN-γ was 48.69 + 28.78 pg/ml while it was 12.99 + 5.70pg/ml in the control group (p <0.001). Significant differences in the level of IFN-γ were observed among confirmed TB patients, clinically diagnosed TB patients and the control group (Mean + SD 59.68 + 28.78, 36.85 + 24.76 and 12.99 + 5.70 pg/ml, respectively). Furthermore, a significant negative correlation was observed between the concentration of IFN-γ in TB patients and the duration of antituberculosis therapy.
Conclusion: IFN-γ level was high in both clinically diagnosed and confirmed TB patients as compared to a control group. Measurement of IFN-γ production is helpful to diagnose active tuberculosis, but further research is required.
کلیدواژه‌ها
ATT؛ ELISA؛ IFN-γ؛ MTB؛ TB
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