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Babaloo, Zohreh, Babaie, Farhad, Farhoodi, Mehdi, Aliparasti, Mohammadreza, Baradaran, Behzad, Almasi, Shohreh, Hosseini, Ahmad. (1389). Interleukin-17A and Interleukin-17F mRNA Expressions in Peripheral Blood Mononuclear Cells of Patients with Multiple Sclerosis. سامانه مدیریت نشریات علمی, 7(4), 1-1. doi: 10.22034/iji.2010.17059
Zohreh Babaloo; Farhad Babaie; Mehdi Farhoodi; Mohammadreza Aliparasti; Behzad Baradaran; Shohreh Almasi; Ahmad Hosseini. "Interleukin-17A and Interleukin-17F mRNA Expressions in Peripheral Blood Mononuclear Cells of Patients with Multiple Sclerosis". سامانه مدیریت نشریات علمی, 7, 4, 1389, 1-1. doi: 10.22034/iji.2010.17059
Babaloo, Zohreh, Babaie, Farhad, Farhoodi, Mehdi, Aliparasti, Mohammadreza, Baradaran, Behzad, Almasi, Shohreh, Hosseini, Ahmad. (1389). 'Interleukin-17A and Interleukin-17F mRNA Expressions in Peripheral Blood Mononuclear Cells of Patients with Multiple Sclerosis', سامانه مدیریت نشریات علمی, 7(4), pp. 1-1. doi: 10.22034/iji.2010.17059
Babaloo, Zohreh, Babaie, Farhad, Farhoodi, Mehdi, Aliparasti, Mohammadreza, Baradaran, Behzad, Almasi, Shohreh, Hosseini, Ahmad. Interleukin-17A and Interleukin-17F mRNA Expressions in Peripheral Blood Mononuclear Cells of Patients with Multiple Sclerosis. سامانه مدیریت نشریات علمی, 1389; 7(4): 1-1. doi: 10.22034/iji.2010.17059

Interleukin-17A and Interleukin-17F mRNA Expressions in Peripheral Blood Mononuclear Cells of Patients with Multiple Sclerosis

Iranian Journal of Immunology
مقاله 1، دوره 7، شماره 4، اسفند 2010، صفحه 1-1    اصل مقاله (13.21 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2010.17059
نویسندگان
Zohreh Babaloo* 1، 2؛ Farhad Babaie1؛ Mehdi Farhoodi2؛ Mohammadreza Aliparasti1؛ Behzad Baradaran1؛ Shohreh Almasi1؛ Ahmad Hosseini1، 3
1Immunology Department, Medicine Faculty
2Neuroscience Research Center, Tabriz University of Medical Sciences,Tabriz, Iran
3Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Bakground: Multiple sclerosis (MS) is a CD4+ T cell-mediated autoimmune disease affecting the central nervous system (CNS). It was previously believed that Th1 cells were pathogenic T cells in experimental autoimmune encephalomyelitis (EAE). However, the functional role of Th1 cells in EAE has been reconsidered upon the discovery of IL-17- producing T cells which are consider as dominant effectors for inducing autoimmune tissue inflammation.
Objective: The objective of this study was to assess the role of IL-17A and IL-17F in MS pathogenesis.
Methods: We evaluated mRNA expression of IL-17A and IL-17F in thirty-five Iranian patients with relapsing–remitting MS (RRMS) and twenty-five healthy controls by Quantitative Real Time PCR.
Results: The results of this study showed a twenty-fold increase in the expression of IL-17A mRNA in MS patients compared to the control group (p < 0.0001 ). IL-17F mRNA expression in MS patients was thirty three-times greater than control group (p = 0.0008). IL-17A mRNA expression in periphery was positively correlated with expression of IL-17F transcripts in MS patients and controls (p < 0.01 and p < 0.05, respectively).
Conclusion: These results indicate the critical role of Th17- mediated cytokines in development of MS which classically has been considered as a Th1-mediated disorder. The results of this study showed, for the first time, the importance of IL-17F in MS immunopathogenesis.
کلیدواژه‌ها
Multiple Sclerosis (MS)؛ IL-17A؛ IL-17F؛ mRNA gene expression
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