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Biria, Mina, Sattari, Mandana, Golpayegani, Mojtaba Vahid, Kooshki, Fahimeh. (1389). Association of Salivary sCD14 Concentration Levels with Early Childhood Caries. سامانه مدیریت نشریات علمی, 7(3), 193-197. doi: 10.22034/iji.2010.17056
Mina Biria; Mandana Sattari; Mojtaba Vahid Golpayegani; Fahimeh Kooshki. "Association of Salivary sCD14 Concentration Levels with Early Childhood Caries". سامانه مدیریت نشریات علمی, 7, 3, 1389, 193-197. doi: 10.22034/iji.2010.17056
Biria, Mina, Sattari, Mandana, Golpayegani, Mojtaba Vahid, Kooshki, Fahimeh. (1389). 'Association of Salivary sCD14 Concentration Levels with Early Childhood Caries', سامانه مدیریت نشریات علمی, 7(3), pp. 193-197. doi: 10.22034/iji.2010.17056
Biria, Mina, Sattari, Mandana, Golpayegani, Mojtaba Vahid, Kooshki, Fahimeh. Association of Salivary sCD14 Concentration Levels with Early Childhood Caries. سامانه مدیریت نشریات علمی, 1389; 7(3): 193-197. doi: 10.22034/iji.2010.17056

Association of Salivary sCD14 Concentration Levels with Early Childhood Caries

Iranian Journal of Immunology
مقاله 7، دوره 7، شماره 3، آذر 2010، صفحه 193-197    اصل مقاله (992.12 K)
نوع مقاله: Short Paper
شناسه دیجیتال (DOI): 10.22034/iji.2010.17056
نویسندگان
Mina Biria* 1؛ Mandana Sattari2؛ Mojtaba Vahid Golpayegani1؛ Fahimeh Kooshki3
1Department of Pediatric Dentistry
2Department of Immunology, Shahid Beheshti University of Medical Sciences,Tehran,Iran
3Department of Pediatric Dentistry, Ghazvin University of Medical Sciences, Ghazvin, Iran
چکیده
Background: Early childhood caries (ECC) is a severe type of dental caries affecting infants and pre-school children. Because of the infectious nature of the disease, the immunologic response by the host plays an essential role in its development.
Objective: This study investigated the association between the presence of salivary sCD14 and ECC.
Methods: This study was carried out on 40 healthy children, of whom 20 were caries-free (CF) and 20 had ECC, within the ages of 36 to 71 months. Unstimulated saliva of the children was collected with disposable needle-less syringe from buccal and labial vestibules. Seven children with ECC received complete treatments. Saliva was collected for a second time after 3 months from this group. The sCD14 levels in salivary samples were analyzed by ELISA method.
Results: Mean concentrations of sCD14 in ECC and CF groups were 57.82 and 31.92 ng/ml respectively (p=0.008). After three months, the mean concentration of sCD14 among the treated children decreased to 11.38 ng/ml, which was significantly lower compared to that of ECC children before intervention (p<0.001), and also CF children (p<0.05).
Conclusion: The increased levels of sCD14 can be considered as a marker of inflammation and innate immune response during ECC.
کلیدواژه‌ها
dental caries؛ Saliva؛ sCD14
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