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FOXP3 and TGF-β Gene Polymorphisms in Allergic Rhinitis | ||
| Iranian Journal of Immunology | ||
| مقاله 4، دوره 8، شماره 4، اسفند 2011، صفحه 218-225 اصل مقاله (231.8 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2011.17029 | ||
| نویسندگان | ||
| Haddi Hassannia1؛ Saeid Abediankenari* 1؛ Javad Ghaffari2 | ||
| 1Department of Immunology and Microbiology | ||
| 2Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran | ||
| چکیده | ||
| Background: Regulatory CD4+T (Treg) cells are effective in maintaining immune tolerance. Objective: To investigate single nucleotide polymorphisms (SNPs) of Transforming Growth Factor β-1 (TGF-β1) and Forkhead Box Protein 3 (FOXP3) genes in Iranian patients with allergic rhinitis (AR). Methods: Variations at codons 10 and 25 of TGF-β1 and FOXP3 at positions -3279 A>C and -924 A>G were evaluated in AR patients and compared with controls. In a case-control study, 155 AR patients and 163 allergy- free controls were genotyped using polymerase chain reaction sequence-specific primer (PCR-SSP) technique. Results: The analysis of the frequency of these SNPs showed that the haplotype formed by FOXP3 -3279 A allele occurred significantly more frequently in patients than controls (odds ratio=1.44, 95% CI=1.312-2.66; p=0.001). Conclusion: Our results suggest that polymorphism in FOXP3 gene is associated with susceptibility to AR. | ||
| کلیدواژه‌ها | ||
| Allergic Rhinitis؛ FOXP3؛ gene polymorphisms؛ TGF-β | ||
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آمار تعداد مشاهده مقاله: 1,699 تعداد دریافت فایل اصل مقاله: 1,223 |
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