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Shotorbani, Siamak Sandoghchian, Zhang, Yue, Baidoo, Samuel Essien, Xu, Huaxi, Ahmadi, Mohammad. (1390). IL-4 Can Inhibit IL-17 Production in Collagen Induced Arthritis. سامانه مدیریت نشریات علمی, 8(4), 209-217. doi: 10.22034/iji.2011.17028
Siamak Sandoghchian Shotorbani; Yue Zhang; Samuel Essien Baidoo; Huaxi Xu; Mohammad Ahmadi. "IL-4 Can Inhibit IL-17 Production in Collagen Induced Arthritis". سامانه مدیریت نشریات علمی, 8, 4, 1390, 209-217. doi: 10.22034/iji.2011.17028
Shotorbani, Siamak Sandoghchian, Zhang, Yue, Baidoo, Samuel Essien, Xu, Huaxi, Ahmadi, Mohammad. (1390). 'IL-4 Can Inhibit IL-17 Production in Collagen Induced Arthritis', سامانه مدیریت نشریات علمی, 8(4), pp. 209-217. doi: 10.22034/iji.2011.17028
Shotorbani, Siamak Sandoghchian, Zhang, Yue, Baidoo, Samuel Essien, Xu, Huaxi, Ahmadi, Mohammad. IL-4 Can Inhibit IL-17 Production in Collagen Induced Arthritis. سامانه مدیریت نشریات علمی, 1390; 8(4): 209-217. doi: 10.22034/iji.2011.17028

IL-4 Can Inhibit IL-17 Production in Collagen Induced Arthritis

Iranian Journal of Immunology
مقاله 3، دوره 8، شماره 4، اسفند 2011، صفحه 209-217    اصل مقاله (1 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2011.17028
نویسندگان
Siamak Sandoghchian Shotorbani1، 2؛ Yue Zhang3؛ Samuel Essien Baidoo1؛ Huaxi Xu1؛ Mohammad Ahmadi* 2
1Department of Immunology, Jiangsu University, Zhenjiang, China
2Tabriz Islamic Azad University, Tabriz, Iran
3Nanjing Province People Hospital, Nanjing, China
چکیده
Background: IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4.
Objective: To examine the effect of IL-4 on IL-17 production and its effect in Collagen- Induced Arthritis (CIA) mice.
Method: In this study, a chicken collagen-II-induced experimental arthritis (CIA) model was used in DBA/1 mice to investigate the relationship between IL-4 and IL-17 as well as other inflammatory factors. On the 38th day after the mice were induced with CIA, the expression of IL-17 and IL-4 as well as IFN-γ and IL-13 in sera of the mice was measured by QRT-PCR and ELISA.
Result: The result of QRT-PCR analysis of IL-17 and IL-4 mRNA levels in the spleen showed that IL-17 is increased significantly at the onset of CIA in the spleen (p<0.01). Meanwhile, IL-17 is generally reduced at the peak of CIA but IL-4 is increased significantly at this peak in the spleen (p<0.05) when the weight of the animal was taken into consideration.
Conclusion: IL-4 can be involved in the production of IL-17 at especially the peak of CIA. These results imply that the inhibition of IL-17 may decrease the expression of IL-1β and IL-6 production which will result in the aggravation of arthritis.
کلیدواژه‌ها
CIA؛ IL-4؛ IL-17
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