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Determination of Soluble HER-2/neu (sHER-2/neu) in Iranian Patients with Lung Cancer | ||
| Iranian Journal of Immunology | ||
| مقاله 2، دوره 3، شماره 2 - شماره پیاپی 9، شهریور 2006، صفحه 61-65 اصل مقاله (69.03 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2006.16960 | ||
| نویسندگان | ||
| Seyyed Mohammad Ali Ghayumi* 1؛ Kambiz Aghasadeghi1؛ Mehrnoosh Dorouchi2؛ Abbas Ghaderi2، 3 | ||
| 1Department of Internal Medicine | ||
| 2Department of Immunology | ||
| 3Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: The HER-2/neu gene is located on chromosome 17q21 and encodes a 185-kDa transmembrane glycoprotein with tyrosine kinase activity reported to be released in soluble form in various malignancies. Objective: To evaluate the clinical significance of soluble Her-2/neu as a diagnostic marker in lung cancer. Methods: Serum levels of soluble HER-2/neu were measured in 43 patients with lung cancer and 42 age and sex matched controls by an enzyme immunoassay method. Results: Mean serum level of soluble Her-2/neu in cancer patients was 6.07±10.37 ng/ml which was significantly higher than the control group (P < 0.05). Cigarette smoking had no effect on the level of soluble HER-2/neu. A cut off value of 6.1ng/ml revealed a high specificity (95%) for diagnosis of lung cancer, but a very low sensitivity (14%). Conclusion: The results of this study show an increased level of soluble HER-2/neu in the sera of lung cancer patients with a high specificity but low sensitivity for diagnosis of lung cancers. | ||
| کلیدواژه‌ها | ||
| Lung Cancer؛ HER2/neu؛ Iran | ||
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