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Pourazar, Abbasali, Salehi, Mansoor, Jafarzadeh, Aabollah, Kazemi Arababadi, Mohammad, Oreizi, Farzad, Shariatinezhad, Keivan. (1384). Detection of HBV DNA in HBsAg Negative Normal Blood Donors. سامانه مدیریت نشریات علمی, 2(3), 172-176.
Abbasali Pourazar; Mansoor Salehi; Aabollah Jafarzadeh; Mohammad Kazemi Arababadi; Farzad Oreizi; Keivan Shariatinezhad. "Detection of HBV DNA in HBsAg Negative Normal Blood Donors". سامانه مدیریت نشریات علمی, 2, 3, 1384, 172-176.
Pourazar, Abbasali, Salehi, Mansoor, Jafarzadeh, Aabollah, Kazemi Arababadi, Mohammad, Oreizi, Farzad, Shariatinezhad, Keivan. (1384). 'Detection of HBV DNA in HBsAg Negative Normal Blood Donors', سامانه مدیریت نشریات علمی, 2(3), pp. 172-176.
Pourazar, Abbasali, Salehi, Mansoor, Jafarzadeh, Aabollah, Kazemi Arababadi, Mohammad, Oreizi, Farzad, Shariatinezhad, Keivan. Detection of HBV DNA in HBsAg Negative Normal Blood Donors. سامانه مدیریت نشریات علمی, 1384; 2(3): 172-176.

Detection of HBV DNA in HBsAg Negative Normal Blood Donors

Iranian Journal of Immunology
مقاله 7، دوره 2، شماره 3 - شماره پیاپی 6، آذر 2005، صفحه 172-176    اصل مقاله (121.89 K)
نوع مقاله: Original Article
نویسندگان
Abbasali Pourazar1؛ Mansoor Salehi1؛ Aabollah Jafarzadeh2؛ Mohammad Kazemi Arababadi2؛ Farzad Oreizi1؛ Keivan Shariatinezhad1
1Immunology Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2Immunology Department, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
چکیده
Background: The risk of infection by transfusion-transmitted viruses has been reduced remarkably. However, a zero-risk blood supply is still desirable. The screening for antibody to HBc (anti-HBc) has been shown as an alternative test for the detection of HBV infection.
Objective: The main aim of this study was to evaluate HBV infection markers and the potential value of anti-HBc testing of blood donors to detect HBV infection.
Methods: In this descriptive cross-sectional study, 545 blood samples were collected and tested for HbsAg using ELISA method. Then all HBsAg negative samples were tested for anti-HBc by the same method. To detect HBV infection, all HBsAg negative and anti-HBc positive samples were tested by PCR for HBV DNA.
Results: All blood samples were HBsAg negative of which, 43 (8%) were anti-HBc positive. From those which were positive for anti-HBc, five samples were also positive for HBV DNA.
Conclusion: Occult HBV infection is a clinical form of HBV infection in which HBsAg is not expressed by HBV and blood samples cannot be screened by ELISA method, therefore more sensitive techniques are needed. Our results demonstrate that a complementary test such as PCR, for detecting HBV DNA, is essential to ensure safety of blood samples.
کلیدواژه‌ها
Occult HBV؛ HBsAg؛ Anti-HBc؛ PCR؛ ELISA
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