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Ataollahi, Mohammad Reza, Aflaki, Elham, Nazarinia, Mohammad Ali, Shenavandeh, Saeedeh, Habibagahi, Zahra, Gharesi-Fard, Behrouz, Kamali-Sarvestani, Eskandar. (1391). Anti-Cardiolipin and Anti-Neutrophil Cytoplasmic Antibodies in Iranian Patients with Behcet's Disease. سامانه مدیریت نشریات علمی, 9(4), 241-247. doi: 10.22034/iji.2012.16877
Mohammad Reza Ataollahi; Elham Aflaki; Mohammad Ali Nazarinia; Saeedeh Shenavandeh; Zahra Habibagahi; Behrouz Gharesi-Fard; Eskandar Kamali-Sarvestani. "Anti-Cardiolipin and Anti-Neutrophil Cytoplasmic Antibodies in Iranian Patients with Behcet's Disease". سامانه مدیریت نشریات علمی, 9, 4, 1391, 241-247. doi: 10.22034/iji.2012.16877
Ataollahi, Mohammad Reza, Aflaki, Elham, Nazarinia, Mohammad Ali, Shenavandeh, Saeedeh, Habibagahi, Zahra, Gharesi-Fard, Behrouz, Kamali-Sarvestani, Eskandar. (1391). 'Anti-Cardiolipin and Anti-Neutrophil Cytoplasmic Antibodies in Iranian Patients with Behcet's Disease', سامانه مدیریت نشریات علمی, 9(4), pp. 241-247. doi: 10.22034/iji.2012.16877
Ataollahi, Mohammad Reza, Aflaki, Elham, Nazarinia, Mohammad Ali, Shenavandeh, Saeedeh, Habibagahi, Zahra, Gharesi-Fard, Behrouz, Kamali-Sarvestani, Eskandar. Anti-Cardiolipin and Anti-Neutrophil Cytoplasmic Antibodies in Iranian Patients with Behcet's Disease. سامانه مدیریت نشریات علمی, 1391; 9(4): 241-247. doi: 10.22034/iji.2012.16877

Anti-Cardiolipin and Anti-Neutrophil Cytoplasmic Antibodies in Iranian Patients with Behcet's Disease

Iranian Journal of Immunology
مقاله 4، دوره 9، شماره 4، اسفند 2012، صفحه 241-247    اصل مقاله (201.31 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2012.16877
نویسندگان
Mohammad Reza Ataollahi1، 2؛ Elham Aflaki3، 4؛ Mohammad Ali Nazarinia3، 4؛ Saeedeh Shenavandeh3، 4؛ Zahra Habibagahi3، 4؛ Behrouz Gharesi-Fard1، 5؛ Eskandar Kamali-Sarvestani* 1، 4
1Depatrment of Immunology
2Student Research Committee
3Department of Rheumatology
4Autoimmune Diseases Research Center
5Infertility Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: The prevalence of anti-Neutrophil Cytoplasmic Antibodies (ANCAs) and anti-Cardiolipin Antibodies (anti-CL Ab) in Behcet’s Disease (BD) and also their roles in vascular involvement is controversial.
Objective: To assess the prevalence of ANCAs and anti-CL Ab as well as their correlations with clinical manifestations in Iranian patients with BD.
Methods: In this case/control study, the sera from 88 patients with BD and 88 healthy controls were evaluated. The levels of ANCAs and anti-CL Ab were measured using indirect ELISA method.
Results: The levels of anti-CL, anti-PR3 and anti-MPO (Myeloperoxidase) IgG autoantibodies between BD patients and healthy controls were not statistically different (p=0.21, p=0.28 and p=0.74, respectively). In addition, there were no significant deferences between BD patients with and without vascular involvement in the levels of anti-CL (1.42 ± 1.24 GPLU/ml and 1.58 ± 1.18 GPLU/ml, respectively; p=0.71), anti-PR3 (0.0 ± 0.0 U/ml and 0.08 ± 0.27 U/ml, respectively; p=0.10) and anti MPO (0.48 ± 0.23 U/ml and 0.52 ± 0.22 U/ml, respectively; p=0.41) IgG autoantibodies. Nevertheless, mean titer of anti-CL IgG was higher in male patients with skin rash than those without skin rash (2.2 ± 0.88 GPLU/ml and 1.11 ± 1.22 GPLU/ml, respectively; p=0.017).
Conclusion: While anti-CL, anti- PR3 and anti-MPO IgG autoantibodies do not play a major role in susceptibility to BD or pathogenesis of vascular involvement in our patients, anti-CL Ab might be involved in skin lesion development in Iranian male BD patients. However, the results should be confirmed in other studies.
کلیدواژه‌ها
ANCA؛ Anticardiolipin antibody؛ Behcet’s Disease
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