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Latifynia, Afshineh, Khamesipour, Ali, Bokaie, Saied, Khansari, Nematollah. (1391). Antioxidants and Proinflamatory Cytokines in the Sera of Patients with Cutaneous Leishmaniasis. سامانه مدیریت نشریات علمی, 9(3), 208-214. doi: 10.22034/iji.2012.16873
Afshineh Latifynia; Ali Khamesipour; Saied Bokaie; Nematollah Khansari. "Antioxidants and Proinflamatory Cytokines in the Sera of Patients with Cutaneous Leishmaniasis". سامانه مدیریت نشریات علمی, 9, 3, 1391, 208-214. doi: 10.22034/iji.2012.16873
Latifynia, Afshineh, Khamesipour, Ali, Bokaie, Saied, Khansari, Nematollah. (1391). 'Antioxidants and Proinflamatory Cytokines in the Sera of Patients with Cutaneous Leishmaniasis', سامانه مدیریت نشریات علمی, 9(3), pp. 208-214. doi: 10.22034/iji.2012.16873
Latifynia, Afshineh, Khamesipour, Ali, Bokaie, Saied, Khansari, Nematollah. Antioxidants and Proinflamatory Cytokines in the Sera of Patients with Cutaneous Leishmaniasis. سامانه مدیریت نشریات علمی, 1391; 9(3): 208-214. doi: 10.22034/iji.2012.16873

Antioxidants and Proinflamatory Cytokines in the Sera of Patients with Cutaneous Leishmaniasis

Iranian Journal of Immunology
مقاله 7، دوره 9، شماره 3، آذر 2012، صفحه 208-214    اصل مقاله (313.43 K)
نوع مقاله: Short Paper
شناسه دیجیتال (DOI): 10.22034/iji.2012.16873
نویسندگان
Afshineh Latifynia* 1؛ Ali Khamesipour2؛ Saied Bokaie3؛ Nematollah Khansari1
1Department of Immunology, Faculty of Medicine
2Leprosy and Dermal Disease Center, Tehran University of Medical Sciences
3Department of Pathobiology, Veterinary Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Leishmania is a significant health problem in many parts of the world. Tumor necrosis factor (TNF) plays an essential role in Leishmania major infections.
Objective: To study the pro-inflammatory cytokines and antioxidants in four groups of cutaneous leishmaniasis patients.
Methods: 39 patients were divided into four groups of: 1) active (acute phase of treatment); 2) non-healing (received treatment for almost two years without recovery); 3) healing (recovered upon treatment); and 4) healed (previously received treatment and achieved complete remission) patients. Serum levels of pro-inflammatory cytokines (IL-1B, TNF-α, IL-6) and serum antioxidant levels were measured by ELISA and FRAP assays, respectively.
Results: While serum antioxidant levels were elevated in the non-healing group, there was no difference among other groups of patients and healthy controls in this regard. Interleukin-1β showed the highest level in the non-healing group followed by the other groups of patients. The mean serum IL-6 level was highest in the non-healing group, but showed no significant change in the other groups. TNF-α and IL-1β levels were non-significantly elevated in the sera of active and non-healing patients.
Conclusion: Pro-inflammatory cytokines IL-1β, TNF-α, IL-6 maybe related to the progression of leishmaniasis. Serum antioxidant levels maybe correlated with patient response to drug treatment.
کلیدواژه‌ها
Antioxidants؛ Cutaneous leishmaniasis؛ Proinflamatory Cytokines
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