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Soveid, Mahmood, Hosseini Asl, Kazem, Ranjbar Omrani, Gholamhossein. (1390). Infection by Cag A Positive Strains of Helicobacter pylori is Associated with Autoimmune Thyroid Disease in Iranian Patients. سامانه مدیریت نشریات علمی, 9(1), 48-52. doi: 10.22034/iji.2012.16856
Mahmood Soveid; Kazem Hosseini Asl; Gholamhossein Ranjbar Omrani. "Infection by Cag A Positive Strains of Helicobacter pylori is Associated with Autoimmune Thyroid Disease in Iranian Patients". سامانه مدیریت نشریات علمی, 9, 1, 1390, 48-52. doi: 10.22034/iji.2012.16856
Soveid, Mahmood, Hosseini Asl, Kazem, Ranjbar Omrani, Gholamhossein. (1390). 'Infection by Cag A Positive Strains of Helicobacter pylori is Associated with Autoimmune Thyroid Disease in Iranian Patients', سامانه مدیریت نشریات علمی, 9(1), pp. 48-52. doi: 10.22034/iji.2012.16856
Soveid, Mahmood, Hosseini Asl, Kazem, Ranjbar Omrani, Gholamhossein. Infection by Cag A Positive Strains of Helicobacter pylori is Associated with Autoimmune Thyroid Disease in Iranian Patients. سامانه مدیریت نشریات علمی, 1390; 9(1): 48-52. doi: 10.22034/iji.2012.16856

Infection by Cag A Positive Strains of Helicobacter pylori is Associated with Autoimmune Thyroid Disease in Iranian Patients

Iranian Journal of Immunology
مقاله 4، دوره 9، شماره 1، خرداد 2012، صفحه 48-52    اصل مقاله (242.58 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2012.16856
نویسندگان
Mahmood Soveid* 1؛ Kazem Hosseini Asl2؛ Gholamhossein Ranjbar Omrani3
1Endocrinology and Metabolism Research Center
2Gastroenterology Unit, Department of Internal Medicine
3Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences. Shiraz, Iran
چکیده
Background: Infectious agents have been suspected as a triggering factor for development of autoimmune thyroid disease (ATD). Some reports from Western countries have suggested association between Helicobacter pylori (HP) infection and ATD.
Objective: To investigate the association of ATD with Cag A seropositivity in a population with high rate and early age of onset of HP infection.
Methods: IgG anti HP and anti Cag A antibodies were measured in 88 patients with ATD and compared with results of 112 healthy individuals.
Results: The rate of infection with HP was not significantly different in patient and control groups, but there was significant association between ATD and infection with Cag A strains (p<0.005). This association was significant for both hypothyroidism (p<0.005) and Graves' disease (p<0.02). Cag A antibody level correlated with titers of thyroid auto antibodies (p<0.001).
Conclusion: In a population with high rate and early age of onset of HP infection, only infection with Cag A positive strains is associated with ATD, and this may be due to immune cross reactivity.
کلیدواژه‌ها
Autoimmune Thyroid Disease؛ Cag A؛ pylori؛ Graves΄ Disease؛ Helicobacter
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