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Lessan-Pezeshki, Mahboob, Amirzargar, Ali Akbar, Golabi, Nooshin, Khatami, Mohammadreza, Einollahi, Behzad, Pourfarziani, Vahid, Khosravi, Farideh, Tajerzadeh, Hassaneh, Nikbin, Behrouz. (1384). Prediction of Rejection in Renal Transplantation by Immune Parameters. سامانه مدیریت نشریات علمی, 2(2), 87-90. doi: 10.22034/iji.2005.16845
Mahboob Lessan-Pezeshki; Ali Akbar Amirzargar; Nooshin Golabi; Mohammadreza Khatami; Behzad Einollahi; Vahid Pourfarziani; Farideh Khosravi; Hassaneh Tajerzadeh; Behrouz Nikbin. "Prediction of Rejection in Renal Transplantation by Immune Parameters". سامانه مدیریت نشریات علمی, 2, 2, 1384, 87-90. doi: 10.22034/iji.2005.16845
Lessan-Pezeshki, Mahboob, Amirzargar, Ali Akbar, Golabi, Nooshin, Khatami, Mohammadreza, Einollahi, Behzad, Pourfarziani, Vahid, Khosravi, Farideh, Tajerzadeh, Hassaneh, Nikbin, Behrouz. (1384). 'Prediction of Rejection in Renal Transplantation by Immune Parameters', سامانه مدیریت نشریات علمی, 2(2), pp. 87-90. doi: 10.22034/iji.2005.16845
Lessan-Pezeshki, Mahboob, Amirzargar, Ali Akbar, Golabi, Nooshin, Khatami, Mohammadreza, Einollahi, Behzad, Pourfarziani, Vahid, Khosravi, Farideh, Tajerzadeh, Hassaneh, Nikbin, Behrouz. Prediction of Rejection in Renal Transplantation by Immune Parameters. سامانه مدیریت نشریات علمی, 1384; 2(2): 87-90. doi: 10.22034/iji.2005.16845

Prediction of Rejection in Renal Transplantation by Immune Parameters

Iranian Journal of Immunology
مقاله 3، دوره 2، شماره 2 - شماره پیاپی 5، شهریور 2005، صفحه 87-90    اصل مقاله (75 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2005.16845
نویسندگان
Mahboob Lessan-Pezeshki؛ Ali Akbar Amirzargar* ؛ Nooshin Golabi؛ Mohammadreza Khatami؛ Behzad Einollahi؛ Vahid Pourfarziani؛ Farideh Khosravi؛ Hassaneh Tajerzadeh؛ Behrouz Nikbin
Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Monitoring of phenotypic characteristics of T-lymphocytes in peripheral blood is commonly performed to give the clinical parameters in the management of kidney transplant recipients.  
Objective: To predict rejection in renal transplantation by immune parameters.
Methods: 16 non-diabetic kidney transplant candidates (4 females and 12 males, age = 20-65 yr, first time transplant) were selected. The transplanted patients were divided into two groups based on the rejection during 3 weeks post transplant: group I (n = 9) without rejection and group II (n = 7) with a rejection episode. Immune parameters including lymphocytes subpopulations (by flowcytometry) and immunoglobulin classes (IgM, IgG, IgA and IgE by nephlometric assay) before and 45 days after transplantation were determined.  
Results: The results of this investigation showed that the level of immunoglobulin IgG, IgM, IgA and IgE decreased post transplantation due to immunosuppressive drugs. CD3, CD4, CD8 T cells count, CD56 NK cells count and CD20 B cells count pre- and post-transplantation did not show any significant differences. The amount of IgE (220   vs. 462 IU/ml), CD3 (62% vs. 69.7%) and CD4 (35% vs. 41.3%) cells increased in group II during rejection episode pre-transplantation. In addition, IgA increased pretransplantation in group I those without rejection episode in comparison with group II with a rejection episode. Forty five days post transplantation IgA (209   vs. 152 mg/dl), IgG (1009 vs. 703 mg/dl) and CD20 (15%   vs. 10%) increased in group I patients.
Conclusion: It is suggestive that pre-transplantation increases IgE, CD3 and CD4 are predictive of acute rejection.
کلیدواژه‌ها
Cytokine؛ Rejection؛ renal transplantation
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