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Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage | ||
| Iranian Journal of Immunology | ||
| مقاله 2، دوره 2، شماره 2 - شماره پیاپی 5، شهریور 2005، صفحه 78-86 اصل مقاله (1.24 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2005.16844 | ||
| نویسندگان | ||
| Mahmoud Orazizadeh* 1؛ Donald M Salter2 | ||
| 1Department of Histology, Medical School, Ahwaz Jondishapour University of Medical Sciences (AJUMS), Ahwaz, Iran | ||
| 2Department of Pathology, Medical School, Edinburgh University, Edinburgh, Scotland, UK | ||
| چکیده | ||
| Background: Previous studies have shown that Galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones. Objective: In the present work, the expression pattern of Galectin-3 in normal and various grades of osteoarthritic (OA) human articular cartilage has been studied. Methods: Using immunohistochemistry and standard western blotting, the in vivo and in vitro expression pattern of Galectin-3 in normal and OA human articular cartilage were assessed. Results: Immunohistochemical studies showed a similar pattern of Galectin-3 expression in normal and mild OA but severe OA showed different strong expression in all zones of human articular cartilage. Conclusion: Increased expression pattern of Galectin-3 in advanced stages of OA may occur as a result of the imbalance of chondrocyte homeostasis that occurs in OA cartilage and provides a condition to modify normal chondrocyte to an OA chondroctye. | ||
| کلیدواژه‌ها | ||
| Articular Cartilage؛ Galectin-3؛ Osteoarthritis | ||
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آمار تعداد مشاهده مقاله: 900 تعداد دریافت فایل اصل مقاله: 711 |
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