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Solooki, Saeed, Khozaei, Arash, Shamsdin, Seyedeh Azra, Emami, Mohammad Jafar, Khademolhosseini, Farnaz. (1392). sCD30 and sCD40L Detection in Patients with Osteosarcoma, Chondrosarcoma and Ewing Sarcoma. سامانه مدیریت نشریات علمی, 10(4), 229-237. doi: 10.22034/iji.2013.16839
Saeed Solooki; Arash Khozaei; Seyedeh Azra Shamsdin; Mohammad Jafar Emami; Farnaz Khademolhosseini. "sCD30 and sCD40L Detection in Patients with Osteosarcoma, Chondrosarcoma and Ewing Sarcoma". سامانه مدیریت نشریات علمی, 10, 4, 1392, 229-237. doi: 10.22034/iji.2013.16839
Solooki, Saeed, Khozaei, Arash, Shamsdin, Seyedeh Azra, Emami, Mohammad Jafar, Khademolhosseini, Farnaz. (1392). 'sCD30 and sCD40L Detection in Patients with Osteosarcoma, Chondrosarcoma and Ewing Sarcoma', سامانه مدیریت نشریات علمی, 10(4), pp. 229-237. doi: 10.22034/iji.2013.16839
Solooki, Saeed, Khozaei, Arash, Shamsdin, Seyedeh Azra, Emami, Mohammad Jafar, Khademolhosseini, Farnaz. sCD30 and sCD40L Detection in Patients with Osteosarcoma, Chondrosarcoma and Ewing Sarcoma. سامانه مدیریت نشریات علمی, 1392; 10(4): 229-237. doi: 10.22034/iji.2013.16839

sCD30 and sCD40L Detection in Patients with Osteosarcoma, Chondrosarcoma and Ewing Sarcoma

Iranian Journal of Immunology
مقاله 4، دوره 10، شماره 4، اسفند 2013، صفحه 229-237    اصل مقاله (207.59 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2013.16839
نویسندگان
Saeed Solooki1؛ Arash Khozaei1؛ Seyedeh Azra Shamsdin* 2؛ Mohammad Jafar Emami1؛ Farnaz Khademolhosseini2
1Department of Orthopedic Surgery, Bone and Joint Disease Research Center, Chamran Hospital
2Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Primary malignant bone tumors are heterogeneous groups of neoplasms, which affect mainly children and adolescents. The most common types are Osteosarcoma, Ewing sarcoma and chondrosarcoma. Elevation of sCD30 and sCD40L has been observed in lymphoma, leukemia and autoimmune disorders.
Objective: To evaluate serum concentrations of sCD30 and sCD40L in patients with primary malignant bone tumors.
Method: Fifty-four cases (31 Osteosarcomas, 14 Ewing sarcomas, and 9 Chondrosarcomas) and 54 healthy controls enrolled in this study. Cases with the history of prior treatment (surgery, chemotherapy and radiotherapy) were excluded from the study. Serum levels of sCD30 and sCD40L were detected by an enzyme linked immunosorbent assay (ELISA).
Results: Mean serum concentration of sCD30 in Ewing sarcoma was significantly higher than that of the control groups (p=0.007), but mean serum concentrations of sCD30 in osteosarcoma and chondrosarcoma groups were not significantly different, compared to the controls (p=0.41 and p=0.11, respectively). Mean serum concentrations of sCD40L in osteosarcoma, Ewing sarcoma and chondrosarcoma groups were significantly higher than that of the control group (p<0.0001). In addition, the mean serum level of sCD40L in chondrosarcoma patients was higher than that of both Ewing sarcoma and osteosarcoma groups (p<0.001).
Conclusion: sCD30 and sCD40L increase in primary bone tumors; however the significant of these findings for diagnosis or prognosis of these tumors needs further investigation.
کلیدواژه‌ها
Bone؛ cancer؛ Sarcoma؛ sCD30؛ sCD40L
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