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Alyasin, Soheila, Karimi, Mohammad Hossein, Amin, Reza, Babaei, Maryam, Darougar, Sepideh. (1392). Interleukin-17 Gene Expression and Serum Levels in Children with Severe Asthma. سامانه مدیریت نشریات علمی, 10(3), 177-185. doi: 10.22034/iji.2013.16834
Soheila Alyasin; Mohammad Hossein Karimi; Reza Amin; Maryam Babaei; Sepideh Darougar. "Interleukin-17 Gene Expression and Serum Levels in Children with Severe Asthma". سامانه مدیریت نشریات علمی, 10, 3, 1392, 177-185. doi: 10.22034/iji.2013.16834
Alyasin, Soheila, Karimi, Mohammad Hossein, Amin, Reza, Babaei, Maryam, Darougar, Sepideh. (1392). 'Interleukin-17 Gene Expression and Serum Levels in Children with Severe Asthma', سامانه مدیریت نشریات علمی, 10(3), pp. 177-185. doi: 10.22034/iji.2013.16834
Alyasin, Soheila, Karimi, Mohammad Hossein, Amin, Reza, Babaei, Maryam, Darougar, Sepideh. Interleukin-17 Gene Expression and Serum Levels in Children with Severe Asthma. سامانه مدیریت نشریات علمی, 1392; 10(3): 177-185. doi: 10.22034/iji.2013.16834

Interleukin-17 Gene Expression and Serum Levels in Children with Severe Asthma

Iranian Journal of Immunology
مقاله 6، دوره 10، شماره 3، آذر 2013، صفحه 177-185    اصل مقاله (264.92 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2013.16834
نویسندگان
Soheila Alyasin1، 2؛ Mohammad Hossein Karimi3؛ Reza Amin1، 2؛ Maryam Babaei1، 2؛ Sepideh Darougar* 1، 2
1Allergy Research Center
2Allergy and Immunology Department, Pediatrics Ward, Shiraz University of Medical Sciences, Shiraz, Iran
3Transplant Research Center
چکیده
Background: IL-17 is a major cytokine player in T cell mediated leukocyte associated inflammation. IL-17 is also recognized to participate in the pathophysiology of asthma.
Objective: To determine the role of IL-17 in predicting severe asthma.
Methods: We obtained serum samples from asthmatic children under the age of 5-year in three different groups of mild (n=33), moderate (n=28) and severe (n=32) persistent asthma. IL-17 serum concentrations and mRNA expression were determined by ELISA and real time PCR assays, respectively.
Results: Serum IL-17 concentrations were significantly higher in patients with severe asthma than the other two groups of children with mild and moderate disease (p=0.00). Mean serum IL-17 values were 142.04 pg/ml in mild group, 180.4 pg/ml in moderate group and 251.25 pg/ml in severe group. IL-17 mRNA levels were also significantly elevated in severe asthmatic patients compared to mild and moderate asthmatic children (p=0.00).
Conclusion: Our data reveal an increase in the serum IL-17 concentrations and IL-17 mRNA expressions in children with severe asthma compared to those with mild and moderate forms of the disease.
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