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Bagheri, Morteza, Amirzargar, Ali Akbar, Ghavamzadeh, Ardeshir, Alimoghadam, Kamran, Khosravi, Farideh, Ansaripour, Bita, Moradi, Batoul, Nikbin, Behrouz. (1383). Cytokine Gene Polymorphisms in Iranian Patients with Beta-Thalassemia Major. سامانه مدیریت نشریات علمی, 2(1), 43-49. doi: 10.22034/iji.2005.16827
Morteza Bagheri; Ali Akbar Amirzargar; Ardeshir Ghavamzadeh; Kamran Alimoghadam; Farideh Khosravi; Bita Ansaripour; Batoul Moradi; Behrouz Nikbin. "Cytokine Gene Polymorphisms in Iranian Patients with Beta-Thalassemia Major". سامانه مدیریت نشریات علمی, 2, 1, 1383, 43-49. doi: 10.22034/iji.2005.16827
Bagheri, Morteza, Amirzargar, Ali Akbar, Ghavamzadeh, Ardeshir, Alimoghadam, Kamran, Khosravi, Farideh, Ansaripour, Bita, Moradi, Batoul, Nikbin, Behrouz. (1383). 'Cytokine Gene Polymorphisms in Iranian Patients with Beta-Thalassemia Major', سامانه مدیریت نشریات علمی, 2(1), pp. 43-49. doi: 10.22034/iji.2005.16827
Bagheri, Morteza, Amirzargar, Ali Akbar, Ghavamzadeh, Ardeshir, Alimoghadam, Kamran, Khosravi, Farideh, Ansaripour, Bita, Moradi, Batoul, Nikbin, Behrouz. Cytokine Gene Polymorphisms in Iranian Patients with Beta-Thalassemia Major. سامانه مدیریت نشریات علمی, 1383; 2(1): 43-49. doi: 10.22034/iji.2005.16827

Cytokine Gene Polymorphisms in Iranian Patients with Beta-Thalassemia Major

Iranian Journal of Immunology
مقاله 5، دوره 2، شماره 1 - شماره پیاپی 4، خرداد 2005، صفحه 43-49    اصل مقاله (47.12 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2005.16827
نویسندگان
Morteza Bagheri1؛ Ali Akbar Amirzargar* 2؛ Ardeshir Ghavamzadeh3؛ Kamran Alimoghadam3؛ Farideh Khosravi2؛ Bita Ansaripour2؛ Batoul Moradi2؛ Behrouz Nikbin2
1Department of Molecular Biology & Genetics, Uromia University of Medical Sciences, Uromia, Iran
2Immunogenetic Laboratory, Department of Immunology, School of Medicine, Tehran University of Medical Sciences
3Hematology-Oncology and BMT Research Center, Shariati Hospital, Tehran, Iran
چکیده
Background: β-thalassemia as a hereditary disease is defined as defective synthesis of   β-globin chains, resulting in erythropoiesis abnormalities and severe anemia. Different studies have shown that cytokines and cytokine gene polymorphisms play a major role in the pathogenesis of   β-thalassemia. Single nucleotide polymorphisms (SNPs) within the promoter region or other regulatory sequences of cytokine genes lead to overall production of cytokines.  
Objective: To analyze the genetic profile of Th1 and Th2 cytokines in Iranian patients with   β-thalassemia major.
Methods: Allelic and genotype frequencies of cytokine genes were determined in 30 thalassemia patients and 40 healthy subjects using PCR-SSP assay. Allele and genotype frequencies were calculated and compared with those of normal controls.  
Results: The results of our study show a significant decrease in A allele at position UTR 5644 IFN-   γ, G alleles at position -238 TNF-   α and 166 IL-2, and C allele at position -590 IL-4. TGF- β   haplotype TG/TG increased whereas TGF-β haplotype CG/CG and IL-10 haplotype GCC/ACC decreased significantly in all patients.  
Conclusion: Data of this investigation suggest that variations among cytokine gene polymorphisms may contribute to the disease susceptibility. A finding which needs to be fairly clarified in other ethnic groups.
کلیدواژه‌ها
β-thalassemia؛ Cytokine Gene Polymorphism
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