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Naderi, Nadereh, Etaati, Zahra, Rezvani Joibari, Mansoreh, Sobhani, Seyed Alireza, Hosseni Tashnizi, Said. (1392). Immune Deviation in Recurrent Vulvovaginal Candidiasis: Correlation with Iron Deficiency Anemia. سامانه مدیریت نشریات علمی, 10(2), 118-126. doi: 10.22034/iji.2013.16819
Nadereh Naderi; Zahra Etaati; Mansoreh Rezvani Joibari; Seyed Alireza Sobhani; Said Hosseni Tashnizi. "Immune Deviation in Recurrent Vulvovaginal Candidiasis: Correlation with Iron Deficiency Anemia". سامانه مدیریت نشریات علمی, 10, 2, 1392, 118-126. doi: 10.22034/iji.2013.16819
Naderi, Nadereh, Etaati, Zahra, Rezvani Joibari, Mansoreh, Sobhani, Seyed Alireza, Hosseni Tashnizi, Said. (1392). 'Immune Deviation in Recurrent Vulvovaginal Candidiasis: Correlation with Iron Deficiency Anemia', سامانه مدیریت نشریات علمی, 10(2), pp. 118-126. doi: 10.22034/iji.2013.16819
Naderi, Nadereh, Etaati, Zahra, Rezvani Joibari, Mansoreh, Sobhani, Seyed Alireza, Hosseni Tashnizi, Said. Immune Deviation in Recurrent Vulvovaginal Candidiasis: Correlation with Iron Deficiency Anemia. سامانه مدیریت نشریات علمی, 1392; 10(2): 118-126. doi: 10.22034/iji.2013.16819

Immune Deviation in Recurrent Vulvovaginal Candidiasis: Correlation with Iron Deficiency Anemia

Iranian Journal of Immunology
مقاله 7، دوره 10، شماره 2، شهریور 2013، صفحه 118-126    اصل مقاله (305.01 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2013.16819
نویسندگان
Nadereh Naderi* 1، 2؛ Zahra Etaati3؛ Mansoreh Rezvani Joibari3؛ Seyed Alireza Sobhani4؛ Said Hosseni Tashnizi5
1Department of Immunology
2Infectious Disease Research Center
3Department of Obstetrics and Gynecology
4Department of Pathology
5Department of Biostatistics, Bandar Abbas School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
چکیده
Background: Iron Deficiency Anemia (IDA) has been controversially linked to IL-4 production in previous studies. A predominant Th1 response leads to resistance against recurrent vulvovaginal candidiasis (RVVC), whereas a Th2 response exacerbates the disease.
Objective: To investigate the possible effect of iron deficiency on the host’s susceptibility to RVVC as a result of the Th1/Th2 cytokine polarization.
Methods: We conducted a case-control study of 92 women in 4 groups based on strict inclusion and exclusion criteria: RVVC+IDA+ group consisted of 23 women with RVVC and IDA; RVVC+ IDA- group consisted of 23 women with RVVC without IDA; RVVC-IDA+ group consisted of 23 women without RVVC and with IDA and RVVC- IDA- group consisted of 23 healthy women. The iron parameters and key cytokines (IFN-γ, IL-10, IL-12, IL-4) were measured in blood samples.
Results: Comparison of IL-4 production between RVVC+ IDA+ (12.2 ± 1.3 pg/ml) and RVVC+ IDA- (2.4 ± 4.0 pg/ml) groups (p=0.044), between RVVC- IDA+ (14.6 ± 1.7 pg/ml) and RVVC- IDA- (1.28 ± 3.6 pg/ml) groups (p=0.006), between RVVC- IDA+ (14.6 ± 1.7 pg/ml) and RVVC+ IDA-) 2.4 ± 4.0 pg/ml) groups (p=0.009) and also between RVVC+ IDA+ and RVVC- IDA- (1.28 ± 3.6 pg/ml) groups (p=0.03) showed significant differences. We found a significant positive correlation between IL-4 and total iron binding capacity (TIBC, p=0.046) and between serum IL-10 and Hb levels (p=0.041) in the RVVC+ IDA- group. There was also a significant negative correlation between serum IL-4 and levels of serum iron (SI, p=0.041) in the RVVC- IDA- group.
Conclusion: It seems that IDA determines the balance between and the intensity of Th1 and Th2 arms of the immune response and leads to a deviation toward Th2 response which could contribute to recurrence of candidiasis.
کلیدواژه‌ها
Cytokine؛ iron deficiency؛ Recurrent Vulvovaginal Candidiasis؛ Th1/Th2
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