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Doroudchi, Mehrnoosh, Dehshiri, Hamidreza, Samsami Dehaghani, Alamtaj. (1383). Placental Transfer of Respiratory Syncytial Virus-Specific IgG in Iranian Mothers. سامانه مدیریت نشریات علمی, 1(3), 183-188. doi: 10.22034/iji.2004.16813
Mehrnoosh Doroudchi; Hamidreza Dehshiri; Alamtaj Samsami Dehaghani. "Placental Transfer of Respiratory Syncytial Virus-Specific IgG in Iranian Mothers". سامانه مدیریت نشریات علمی, 1, 3, 1383, 183-188. doi: 10.22034/iji.2004.16813
Doroudchi, Mehrnoosh, Dehshiri, Hamidreza, Samsami Dehaghani, Alamtaj. (1383). 'Placental Transfer of Respiratory Syncytial Virus-Specific IgG in Iranian Mothers', سامانه مدیریت نشریات علمی, 1(3), pp. 183-188. doi: 10.22034/iji.2004.16813
Doroudchi, Mehrnoosh, Dehshiri, Hamidreza, Samsami Dehaghani, Alamtaj. Placental Transfer of Respiratory Syncytial Virus-Specific IgG in Iranian Mothers. سامانه مدیریت نشریات علمی, 1383; 1(3): 183-188. doi: 10.22034/iji.2004.16813

Placental Transfer of Respiratory Syncytial Virus-Specific IgG in Iranian Mothers

Iranian Journal of Immunology
مقاله 6، دوره 1، شماره 3، اسفند 2004، صفحه 183-188    اصل مقاله (190.82 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2004.16813
نویسندگان
Mehrnoosh Doroudchi* 1، 2؛ Hamidreza Dehshiri3؛ Alamtaj Samsami Dehaghani4
1Department of Immunology
2Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz
3Department of Biology, Islamic Azad University, Jahrom
4Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Respiratory Syncytical virus infection is the most common cause of bronchiolitis and viral pneumonia in infancy.
Objective: To investigate the placental transfer of RSV-specific IgG in Iranian mothers.
Methods: The antibodies were measured in sera of 146 mother/newborn pairs using a commercially available indirect Enzyme Linked Immunosorbent Assay (ELISA). The studied subjects were among healthy pregnant women who attended to the Zeinabieh Hospital of Shiraz University of Medical Sciences in a one year period.
Results: A highly significant correlation was observed between RSV-specific IgG in newborns and mothers (r = 0.88). However, mean RSV-specific IgG antibodies in neonates was significantly higher than that of their mothers (P = 0.019). In addition, the mean cord/maternal ratio of RSV-specific IgG was detected to be 1.27 ± 0.60. Maternal blood group, age, parity, previous abortions and neonatal gestational age had no correlation with placental transfer of RSV-specific IgG antibodies.
Conclusion: Our finding demonstrates that placental transfer of RSV-specific IgG antibodies is an active process and the main factor that influences this transfer is maternal concentration of these immunoglobulins.
کلیدواژه‌ها
IgG؛ Iranian؛ Placental Transfer؛ RSV
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