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Zainodini, Nahid, Hassanshahi, Gholamhossein, Kazemi Arababadi, Mohammad, Khorramdelazad, Hossein, Mirzaei, Afshin. (1391). Differential Expression of CXCL1, CXCL9 CXCL10 and CXCL12 Chemokines in Alopecia Areata. سامانه مدیریت نشریات علمی, 10(1), 40-46. doi: 10.22034/iji.2013.16802
Nahid Zainodini; Gholamhossein Hassanshahi; Mohammad Kazemi Arababadi; Hossein Khorramdelazad; Afshin Mirzaei. "Differential Expression of CXCL1, CXCL9 CXCL10 and CXCL12 Chemokines in Alopecia Areata". سامانه مدیریت نشریات علمی, 10, 1, 1391, 40-46. doi: 10.22034/iji.2013.16802
Zainodini, Nahid, Hassanshahi, Gholamhossein, Kazemi Arababadi, Mohammad, Khorramdelazad, Hossein, Mirzaei, Afshin. (1391). 'Differential Expression of CXCL1, CXCL9 CXCL10 and CXCL12 Chemokines in Alopecia Areata', سامانه مدیریت نشریات علمی, 10(1), pp. 40-46. doi: 10.22034/iji.2013.16802
Zainodini, Nahid, Hassanshahi, Gholamhossein, Kazemi Arababadi, Mohammad, Khorramdelazad, Hossein, Mirzaei, Afshin. Differential Expression of CXCL1, CXCL9 CXCL10 and CXCL12 Chemokines in Alopecia Areata. سامانه مدیریت نشریات علمی, 1391; 10(1): 40-46. doi: 10.22034/iji.2013.16802

Differential Expression of CXCL1, CXCL9 CXCL10 and CXCL12 Chemokines in Alopecia Areata

Iranian Journal of Immunology
مقاله 5، دوره 10، شماره 1، خرداد 2013، صفحه 40-46    اصل مقاله (243.29 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2013.16802
نویسندگان
Nahid Zainodini1؛ Gholamhossein Hassanshahi2؛ Mohammad Kazemi Arababadi1؛ Hossein Khorramdelazad2؛ Afshin Mirzaei* 3
1Immunology of Infectious Diseases Research Center
2Molecular Medicine Research Center
3Department of Dermatology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
چکیده
Background: Alopecia Areata (AA) is a non-scarring, autoimmune disorder which causes hair loss. Inflammatory reactions are involved in hair loss of the scalp and/or body. The involvement of chemokine receptors in the pathogenesis of AA is well defined among which, CXCL1 acts on neutrophils and CXCL9, CXCL10 and CXCL12 and serve as T lymphocytes recruiters.
Objective: To study the serum levels of ELR+ and ELR- CXCL1, CXCL9, CXCL10 and CXCL12 in the patients suffering from AA and healthy controls.
Methods: The study population of consisted of 30 patients suffering from AA and 30 healthy controls. Serum concentrations of CXCL1, CXCL9, CXCL10 and CXCL12 were measured using enzymelinked immunosorbent assay (ELISA).
Results: Current results showed that AA patients had significantly elevated serum levels of CXCL9 and CXCL10 in comparison to controls (p<0.001). These results also demonstrated that serum levels of CXCL1 and CXCL12 were significantly decreased in AA patients compared to control (p<0.001).
Conclusion: CXCL9 and CXCL10 are elevated in the AA patients and may be involved in the recruitment of T lymphocytes to the inflamed tissues. Moreover, due to the significant role played by these chemokines in angiogenesis/angiostatis phenomenon they could be considered as useful biomarkers in AA diagnosis and therapy.
کلیدواژه‌ها
Alopecia areata؛ Chemokine؛ CXCL1؛ CXCL9؛ CXCL10؛ CXCL12
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