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Farjadian, Shirin, Rahimifar, Shahrzad, Erfani, Nasrollah, Lotfi, Ramin. (1391). Effect of Thermal Stress on MICA/B Induction in a Human Liposarcoma Cell Line. سامانه مدیریت نشریات علمی, 10(1), 31-39. doi: 10.22034/iji.2013.16801
Shirin Farjadian; Shahrzad Rahimifar; Nasrollah Erfani; Ramin Lotfi. "Effect of Thermal Stress on MICA/B Induction in a Human Liposarcoma Cell Line". سامانه مدیریت نشریات علمی, 10, 1, 1391, 31-39. doi: 10.22034/iji.2013.16801
Farjadian, Shirin, Rahimifar, Shahrzad, Erfani, Nasrollah, Lotfi, Ramin. (1391). 'Effect of Thermal Stress on MICA/B Induction in a Human Liposarcoma Cell Line', سامانه مدیریت نشریات علمی, 10(1), pp. 31-39. doi: 10.22034/iji.2013.16801
Farjadian, Shirin, Rahimifar, Shahrzad, Erfani, Nasrollah, Lotfi, Ramin. Effect of Thermal Stress on MICA/B Induction in a Human Liposarcoma Cell Line. سامانه مدیریت نشریات علمی, 1391; 10(1): 31-39. doi: 10.22034/iji.2013.16801

Effect of Thermal Stress on MICA/B Induction in a Human Liposarcoma Cell Line

Iranian Journal of Immunology
مقاله 4، دوره 10، شماره 1، خرداد 2013، صفحه 31-39    اصل مقاله (784.72 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2013.16801
نویسندگان
Shirin Farjadian* 1، 2؛ Shahrzad Rahimifar1؛ Nasrollah Erfani3؛ Ramin Lotfi4
1Department of Immunology
2Allergy Research Center
3Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
4Institute of Transfusion Medicine, University of Ulm, Ulm, Germany
چکیده
Background: A possible mechanism by which hyperthermia enhances tumor immunogenicity is the induction of NKG2D ligands on tumor cells. Although the expression of MHC class I chain-related protein A and B (MICA/B) has previously been reported in different carcinomas, there is no information about MICA/B expression in liposarcomas.
Objective: To investigate MICA/B induction in a human liposarcoma cell line (SW-872) after thermotherapy.
Methods: SW-872 and HeLa cell lines were subjected to thermal stress for 1 h at 42, 44 and 46C, and after 2, 4 and 6 h of incubation at 37C, MICA/B expression was assessed at the mRNA and protein levels.
Results: Despite high levels of MICA/B transcripts in SW-872 cells at baseline, the expression of these genes decreased significantly at both the mRNA and protein levels after almost all thermal treatments.
Conclusion: Our data conclude that thermotherapy under 42-46°C had no effect on MICA/B induction on SW-872 liposarcoma cell line but the effects of fever-range temperatures remain to be tested on this cell line.
کلیدواژه‌ها
Hyperthermia؛ Liposarcoma؛ MICA/B
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