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Hamidinia, Maryam, Ghafourian Boroujernia, Mehri, Talaiezadeh, Abdolhassan, Solgi, Ghasem, Taghdiri, Maryam, Khodadadi, Ali. (1391). Concomitant Increase of OX40 and FOXP3 Transcripts in Peripheral Blood of Patients with Breast Cancer. سامانه مدیریت نشریات علمی, 10(1), 22-30. doi: 10.22034/iji.2013.16800
Maryam Hamidinia; Mehri Ghafourian Boroujernia; Abdolhassan Talaiezadeh; Ghasem Solgi; Maryam Taghdiri; Ali Khodadadi. "Concomitant Increase of OX40 and FOXP3 Transcripts in Peripheral Blood of Patients with Breast Cancer". سامانه مدیریت نشریات علمی, 10, 1, 1391, 22-30. doi: 10.22034/iji.2013.16800
Hamidinia, Maryam, Ghafourian Boroujernia, Mehri, Talaiezadeh, Abdolhassan, Solgi, Ghasem, Taghdiri, Maryam, Khodadadi, Ali. (1391). 'Concomitant Increase of OX40 and FOXP3 Transcripts in Peripheral Blood of Patients with Breast Cancer', سامانه مدیریت نشریات علمی, 10(1), pp. 22-30. doi: 10.22034/iji.2013.16800
Hamidinia, Maryam, Ghafourian Boroujernia, Mehri, Talaiezadeh, Abdolhassan, Solgi, Ghasem, Taghdiri, Maryam, Khodadadi, Ali. Concomitant Increase of OX40 and FOXP3 Transcripts in Peripheral Blood of Patients with Breast Cancer. سامانه مدیریت نشریات علمی, 1391; 10(1): 22-30. doi: 10.22034/iji.2013.16800

Concomitant Increase of OX40 and FOXP3 Transcripts in Peripheral Blood of Patients with Breast Cancer

Iranian Journal of Immunology
مقاله 3، دوره 10، شماره 1، خرداد 2013، صفحه 22-30    اصل مقاله (332.01 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2013.16800
نویسندگان
Maryam Hamidinia1؛ Mehri Ghafourian Boroujernia2؛ Abdolhassan Talaiezadeh3؛ Ghasem Solgi4؛ Maryam Taghdiri1؛ Ali Khodadadi1
1Department of Immunology and Cancer Research Center
2Department of Immunology, Faculty of Medicine
3Department of Surgery, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz
4Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
چکیده
Background: Regulatory T cells (T-regs) have an important role in cancer by suppression of protective antitumor immune responses. Regulatory T cells express the forkhead/winged helix transcription factor (FOXP3) and OX40 molecules which have important regulatory roles in the immune system.
Objective: To evaluate FOXP3 and OX40 transcripts in the peripheral blood mononuclear cells of women with breast cancer.
Methods: Blood samples from 40 women with histologically-confirmed infiltrating ductal carcinoma of the breast and 40 healthy volunteer women without a history of malignancy or autoimmune disorders were collected. The abundance of FOXP3 and OX40 gene transcripts were determined by quantitative real-time PCR (qRT-PCR).
Results: There was a significant positive correlation between FOXP3 and OX40 gene expression in women with breast cancer in a stage dependent manner.
Conclusion: This finding emphasizes the importance of T-regs as predominant targets for breast cancer immunotherapy.
کلیدواژه‌ها
Breast cancer؛ FOXP3؛ OX40
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