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Nikoo, Mohammad Hossein, Taghavian, Seyed Rahmatollah, Golmoghaddam, Hossein, Arandi, Narges, Ardekani, Alireza Abdi, Doroudchi, Mehrnoosh. (1393). Increased IL-17A in Atrial Fibrillation Correlates with Neutrophil to Lymphocyte Ratio. سامانه مدیریت نشریات علمی, 11(4), 246-258. doi: 10.22034/iji.2014.16785
Mohammad Hossein Nikoo; Seyed Rahmatollah Taghavian; Hossein Golmoghaddam; Narges Arandi; Alireza Abdi Ardekani; Mehrnoosh Doroudchi. "Increased IL-17A in Atrial Fibrillation Correlates with Neutrophil to Lymphocyte Ratio". سامانه مدیریت نشریات علمی, 11, 4, 1393, 246-258. doi: 10.22034/iji.2014.16785
Nikoo, Mohammad Hossein, Taghavian, Seyed Rahmatollah, Golmoghaddam, Hossein, Arandi, Narges, Ardekani, Alireza Abdi, Doroudchi, Mehrnoosh. (1393). 'Increased IL-17A in Atrial Fibrillation Correlates with Neutrophil to Lymphocyte Ratio', سامانه مدیریت نشریات علمی, 11(4), pp. 246-258. doi: 10.22034/iji.2014.16785
Nikoo, Mohammad Hossein, Taghavian, Seyed Rahmatollah, Golmoghaddam, Hossein, Arandi, Narges, Ardekani, Alireza Abdi, Doroudchi, Mehrnoosh. Increased IL-17A in Atrial Fibrillation Correlates with Neutrophil to Lymphocyte Ratio. سامانه مدیریت نشریات علمی, 1393; 11(4): 246-258. doi: 10.22034/iji.2014.16785

Increased IL-17A in Atrial Fibrillation Correlates with Neutrophil to Lymphocyte Ratio

Iranian Journal of Immunology
مقاله 3، دوره 11، شماره 4، اسفند 2014، صفحه 246-258    اصل مقاله (289.21 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2014.16785
نویسندگان
Mohammad Hossein Nikoo1، 2؛ Seyed Rahmatollah Taghavian2؛ Hossein Golmoghaddam3؛ Narges Arandi3؛ Alireza Abdi Ardekani2؛ Mehrnoosh Doroudchi* 3
1Cardiovascular Research Center
2Department of Cardiology
3Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Atrial Fibrillation (AF) is the most common cardiac arrhythmia and an independent risk factor for stroke among the elderly. A role for inflammation in the atrial remodeling as well as development and recurrence of AF is known.
Objective: To compare IL-17A between patients with different types of AF and healthy individuals.
Methods: IL-17A was measured in sera of 112 patients and 107 healthy age/sexmatched controls using ELISA assay. In sera of 26 patients with elevated IL-17A (>1 Pg/ml), CCL5 and CCL18 levels were also measured.
Results: IL-17A was significantly increased in patients with AF compared to controls (1.28 ± 3.5 vs. 0.19 ± 0.64 Pg/ml, p=0.001). There was no significant difference in the level of IL-17A between different types of AF. IL-17A was significantly higher in patients with a history of coronary artery bypass graft compared to other patients (p=0.01). A significant positive correlation between IL-17A and CCL18 concentration was found (p=0.001). An increase in the Neutrophil/Lymphocyte ratio (NLR) was observed in patients with elevated serum IL-17A compared to other patients (p=0.006). Male patients showed higher increase in NLR (p=0.007) which was accompanied by a decrease in CCL5 (p=0.000) and a marginal increase in CCL18 (p=0.085) compared to females. There was an increase in CCL5 levels in patients receiving Acetylsalicylic Acid (ASA) therapy (p=0.046).
Conclusions: The increase in IL-17A levels is related to the AF pathology mediated by neutrophils and monocytes. The current study signifies the role of immune cells and cytokines in the pathology of AF.
کلیدواژه‌ها
Atrial Fibrillation؛ CABG؛ CCL5؛ CCL18؛ IL-17A؛ Neutrophil
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