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Shaygannejad, Vahid, Montazeri, Saeed, Jamshidian, Azam, Tahani, Soheil, Gharagozloo, Marjan, Ashtari, Fereshteh, Vesal, Sahar, Hasheminia, Seyed Javad, Dehghani, Leila. (1393). Correlation of Midkine Serum Level with Pro- and Anti-Inflamatory Cytokines in Multiple Sclerosis. سامانه مدیریت نشریات علمی, 11(2), 134-138. doi: 10.22034/iji.2014.16774
Vahid Shaygannejad; Saeed Montazeri; Azam Jamshidian; Soheil Tahani; Marjan Gharagozloo; Fereshteh Ashtari; Sahar Vesal; Seyed Javad Hasheminia; Leila Dehghani. "Correlation of Midkine Serum Level with Pro- and Anti-Inflamatory Cytokines in Multiple Sclerosis". سامانه مدیریت نشریات علمی, 11, 2, 1393, 134-138. doi: 10.22034/iji.2014.16774
Shaygannejad, Vahid, Montazeri, Saeed, Jamshidian, Azam, Tahani, Soheil, Gharagozloo, Marjan, Ashtari, Fereshteh, Vesal, Sahar, Hasheminia, Seyed Javad, Dehghani, Leila. (1393). 'Correlation of Midkine Serum Level with Pro- and Anti-Inflamatory Cytokines in Multiple Sclerosis', سامانه مدیریت نشریات علمی, 11(2), pp. 134-138. doi: 10.22034/iji.2014.16774
Shaygannejad, Vahid, Montazeri, Saeed, Jamshidian, Azam, Tahani, Soheil, Gharagozloo, Marjan, Ashtari, Fereshteh, Vesal, Sahar, Hasheminia, Seyed Javad, Dehghani, Leila. Correlation of Midkine Serum Level with Pro- and Anti-Inflamatory Cytokines in Multiple Sclerosis. سامانه مدیریت نشریات علمی, 1393; 11(2): 134-138. doi: 10.22034/iji.2014.16774

Correlation of Midkine Serum Level with Pro- and Anti-Inflamatory Cytokines in Multiple Sclerosis

Iranian Journal of Immunology
مقاله 8، دوره 11، شماره 2، شهریور 2014، صفحه 134-138    اصل مقاله (231.36 K)
نوع مقاله: Short Paper
شناسه دیجیتال (DOI): 10.22034/iji.2014.16774
نویسندگان
Vahid Shaygannejad1؛ Saeed Montazeri2؛ Azam Jamshidian3؛ Soheil Tahani1، 4؛ Marjan Gharagozloo5؛ Fereshteh Ashtari1؛ Sahar Vesal1؛ Seyed Javad Hasheminia4؛ Leila Dehghani* 1، 4
1Department of Neurology and Isfahan Neurosciences Research Center
2Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan
3Immunology and Microbiology Department, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord
4Department of Medical Sciences, Najafabad Branch, Islamic Azad University, Isfahan, Iran
5Department of Immunology, School of Medicine, Isfahan University of Medical Sciences
چکیده
Background: Midkine (MK) is a heparin-binding growth factor with promoting effects in inflammatory responses through enhancing leukocytes migration.
Objective: To study the correlation between MK serum levels and concentration of inflammatory cytokines in Multiple Sclerosis (MS) patients.
Methods: We evaluated the MK level and its relationship with inflammatory cytokines (IL-17 and IL-23) and antiinflammatory ones (IL-10 and TGF-β) in multiple sclerosis (MS) patients. The serum concentrations of MK and cytokines were assessed by ELISA in 32 MS patients in comparison with 32 healthy subjects.
Results: Our data showed that the MK concentration in MS patients is lower than healthy controls (341.15 ± 40.71 Pg/ml vs. 620.15 ± 98.61 Pg/ml, respectively, p=0.015). We also observed a significant decrease in IL-10, IL-23, and TGF-β cytokine levels in MS patients. There was a significant correlation between MK and IL-23 concentrations in our study (r = +0.829, p≤0.001).
Conclusion: These results confirm a role for MK in inflammatory reactions in MS.
کلیدواژه‌ها
IL-10؛ IL-17؛ IL-23؛ Midkine؛ Multiple Sclerosis؛ TGF-β
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