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Bahadori, Motahareh, Zarei, Saeed, Zarnani, Amir Hassan, Zarei, Omid, Idali, Farah, Hadavi, Reza, Jeddi-Tehrani, Mahmood. (1393). IL-6, IL-10 and IL-17 Gene Polymorphisms in Iranian Women with Recurrent Miscarriage. سامانه مدیریت نشریات علمی, 11(2), 97-104. doi: 10.22034/iji.2014.16770
Motahareh Bahadori; Saeed Zarei; Amir Hassan Zarnani; Omid Zarei; Farah Idali; Reza Hadavi; Mahmood Jeddi-Tehrani. "IL-6, IL-10 and IL-17 Gene Polymorphisms in Iranian Women with Recurrent Miscarriage". سامانه مدیریت نشریات علمی, 11, 2, 1393, 97-104. doi: 10.22034/iji.2014.16770
Bahadori, Motahareh, Zarei, Saeed, Zarnani, Amir Hassan, Zarei, Omid, Idali, Farah, Hadavi, Reza, Jeddi-Tehrani, Mahmood. (1393). 'IL-6, IL-10 and IL-17 Gene Polymorphisms in Iranian Women with Recurrent Miscarriage', سامانه مدیریت نشریات علمی, 11(2), pp. 97-104. doi: 10.22034/iji.2014.16770
Bahadori, Motahareh, Zarei, Saeed, Zarnani, Amir Hassan, Zarei, Omid, Idali, Farah, Hadavi, Reza, Jeddi-Tehrani, Mahmood. IL-6, IL-10 and IL-17 Gene Polymorphisms in Iranian Women with Recurrent Miscarriage. سامانه مدیریت نشریات علمی, 1393; 11(2): 97-104. doi: 10.22034/iji.2014.16770

IL-6, IL-10 and IL-17 Gene Polymorphisms in Iranian Women with Recurrent Miscarriage

Iranian Journal of Immunology
مقاله 4، دوره 11، شماره 2، شهریور 2014، صفحه 97-104    اصل مقاله (211.82 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2014.16770
نویسندگان
Motahareh Bahadori1؛ Saeed Zarei2؛ Amir Hassan Zarnani3، 4؛ Omid Zarei5؛ Farah Idali6؛ Reza Hadavi1؛ Mahmood Jeddi-Tehrani* 1
1Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran
2Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz
3Nano biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran
4Immunology Research Center, School of Medicine, Iran University of Medical Sciences, Tehran
5Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz
6Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
چکیده
Background: Pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (RM).
Objective: To investigate the association between RM and five polymorphisms of cytokine genes, interleukin 10 (IL-10), (-592 A/C, -819 C/T, -1082 A/G), IL-6 (-174 C/G) and IL-17 (-197 G/A) in Iranian women.
Method: Polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP) was performed to determine the frequencies of the IL-6, IL-10 and IL-17 gene polymorphisms in 85 women with RM compared with 104 healthy controls.
Results: The frequencies of IL- 10 promoter gene polymorphisms (-592 A/C and -819 C/T) were significantly higher in RM women than those in controls (p=0.003). However, no statistically significant differences were observed in the frequencies of IL-6 (-174 C/G), IL-10 (-1082 A/G) and IL-17 (-197 G/A) polymorphisms between RM women and controls.
Conclusion: These results suggest that IL-10 gene polymorphism screening might have some relevance in patients with RM, a suggestion which requires further studies.
کلیدواژه‌ها
Cytokine؛ Gene Polymorphism؛ PCR-RFLP؛ Recurrent Miscarriage
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