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The Effect of HLA-DRB1 on Cholecystitis | ||
| Iranian Journal of Immunology | ||
| مقاله 7، دوره 12، شماره 2، شهریور 2015، صفحه 149-155 اصل مقاله (119.9 K) | ||
| نوع مقاله: Short Paper | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2015.16744 | ||
| نویسندگان | ||
| Tawfik Jasim Mohammad Al-Marzook؛ Batool Mutar Mahdi؛ Hyam Raouf؛ Haider Hashim Zalzala؛ Laheeb Ali Abid؛ Zena Nehad | ||
| Department of Microbiology, Al-Kindy College of Medicine, Baghdad University, Baghdad, Iraq | ||
| چکیده | ||
| Background: Cholecystitis is one of the major digestive diseases. Its prevalence is particularly high in some populations. Significant risk factors associated with cholecystitis include age, sex, obesity, diet, parity and type 2 diabetes. Objective: To determine the association between HLA-DRB1 and cholecystitis. Methods: This casecontrol study included forty Iraqi Arab patients who had cholecystitis with multiple calculi treated by cholecystectomy admitted in the surgical ward at Al-Kindy Teaching Hospital Baghdad between September -2013 to June -2014. The control group consisted of forty healthy volunteers among the staff of Al-Kindy College of Medicine. Control and cholecystitis patients groups were typed for identifying the DRB1* alleles using DNA-based methodology (PCR-SSOP). Results: There was an increased frequency of HLA-DRB1*0301 in patients with cholecystitis compared with healthy controls (p=0.0442, odd ratio=4.1111, 95% CI: 1.0372-16.2949). Conclusion: HLADRB1*0301, as a genetic factor, seems to have an association with cholecystitis. | ||
| کلیدواژه‌ها | ||
| Cholecystitis؛ Molecular؛ Genetic | ||
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آمار تعداد مشاهده مقاله: 1,278 تعداد دریافت فایل اصل مقاله: 966 |
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