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Ahmadi, Ali, Poursasan, Najmeh, Amani, Jafar, Salimian, Jafar. (1393). Adverse Effect of T-2 Toxin and the Protective Role of Selenium and Vitamin E on Peripheral Blood B lymphocytes. سامانه مدیریت نشریات علمی, 12(1), 64-69. doi: 10.22034/iji.2015.16735
Ali Ahmadi; Najmeh Poursasan; Jafar Amani; Jafar Salimian. "Adverse Effect of T-2 Toxin and the Protective Role of Selenium and Vitamin E on Peripheral Blood B lymphocytes". سامانه مدیریت نشریات علمی, 12, 1, 1393, 64-69. doi: 10.22034/iji.2015.16735
Ahmadi, Ali, Poursasan, Najmeh, Amani, Jafar, Salimian, Jafar. (1393). 'Adverse Effect of T-2 Toxin and the Protective Role of Selenium and Vitamin E on Peripheral Blood B lymphocytes', سامانه مدیریت نشریات علمی, 12(1), pp. 64-69. doi: 10.22034/iji.2015.16735
Ahmadi, Ali, Poursasan, Najmeh, Amani, Jafar, Salimian, Jafar. Adverse Effect of T-2 Toxin and the Protective Role of Selenium and Vitamin E on Peripheral Blood B lymphocytes. سامانه مدیریت نشریات علمی, 1393; 12(1): 64-69. doi: 10.22034/iji.2015.16735

Adverse Effect of T-2 Toxin and the Protective Role of Selenium and Vitamin E on Peripheral Blood B lymphocytes

Iranian Journal of Immunology
مقاله 6، دوره 12، شماره 1، خرداد 2015، صفحه 64-69    اصل مقاله (364.38 K)
نوع مقاله: Short Paper
شناسه دیجیتال (DOI): 10.22034/iji.2015.16735
نویسندگان
Ali Ahmadi1؛ Najmeh Poursasan2؛ Jafar Amani1؛ Jafar Salimian* 3
1Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences
2Institute of Biochemistry and Biophysics, University of Tehran
3Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
چکیده
Background: T-2 mycotoxin belongs to the Trichothecene family and has damaging effects on the immune system.
Objective: To investigate the toxic effect of T-2 toxin on the percentage of peripheral blood B lymphocytes and the potential protective role of selenium and vitamin E.
Method: Frequencies of B lymphocytes (CD19+ ) were analyzed after injection of sublethal doses of T-2 toxin into Balb/c mice at different time points, using flowcytometry. Additionally, the effects of selenium and vitamin E on B lymphocyte, as either prophylaxis or simultaneously administered with T-2 toxin, were investigated.
Results: After injection of a sublethal dose of T-2 toxin, the number of B cells (CD19+ ) significantly decreased at 12 h and became normal at 72 h. When selenium was injected both 24 h before and simultaneously with T-2 toxin, it was able to inhibit B lymphocyte (CD19+) reduction. In contrast, injecting vitamin E, 24 h before or simultaneously with T-2 toxin did not regulate B lymphocyte alteration.
Conclusion: Selenium plays pivotal role on altered B lymphocyte subset induced by T-2 toxin comparing to vitamin E.
کلیدواژه‌ها
B Lymphocytes؛ Flowcytometry؛ Selenium؛ T-2 toxin؛ Vitamin E
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