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Razmkhah, Mahboobeh, Abedi, Nadieh, Hosseini, Ahmad, Imani, Mohammad Taghi, Talei, Abdol-Rasoul, Ghaderi, Abbas. (1393). Induction of T Regulatory Subsets from Naïve CD4+ T Cells after Exposure to Breast Cancer Adipose Derived Stem Cells. سامانه مدیریت نشریات علمی, 12(1), 1-15. doi: 10.22034/iji.2015.16730
Mahboobeh Razmkhah; Nadieh Abedi; Ahmad Hosseini; Mohammad Taghi Imani; Abdol-Rasoul Talei; Abbas Ghaderi. "Induction of T Regulatory Subsets from Naïve CD4+ T Cells after Exposure to Breast Cancer Adipose Derived Stem Cells". سامانه مدیریت نشریات علمی, 12, 1, 1393, 1-15. doi: 10.22034/iji.2015.16730
Razmkhah, Mahboobeh, Abedi, Nadieh, Hosseini, Ahmad, Imani, Mohammad Taghi, Talei, Abdol-Rasoul, Ghaderi, Abbas. (1393). 'Induction of T Regulatory Subsets from Naïve CD4+ T Cells after Exposure to Breast Cancer Adipose Derived Stem Cells', سامانه مدیریت نشریات علمی, 12(1), pp. 1-15. doi: 10.22034/iji.2015.16730
Razmkhah, Mahboobeh, Abedi, Nadieh, Hosseini, Ahmad, Imani, Mohammad Taghi, Talei, Abdol-Rasoul, Ghaderi, Abbas. Induction of T Regulatory Subsets from Naïve CD4+ T Cells after Exposure to Breast Cancer Adipose Derived Stem Cells. سامانه مدیریت نشریات علمی, 1393; 12(1): 1-15. doi: 10.22034/iji.2015.16730

Induction of T Regulatory Subsets from Naïve CD4+ T Cells after Exposure to Breast Cancer Adipose Derived Stem Cells

Iranian Journal of Immunology
مقاله 1، دوره 12، شماره 1، خرداد 2015، صفحه 1-15    اصل مقاله (1.45 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2015.16730
نویسندگان
Mahboobeh Razmkhah1؛ Nadieh Abedi1؛ Ahmad Hosseini1؛ Mohammad Taghi Imani2؛ Abdol-Rasoul Talei3؛ Abbas Ghaderi* 1، 4
1Shiraz Institute for Cancer Research
2Department of Plastic Surgery
3Department of Surgery
4Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Adipose derived stem cells (ASCs) provoke the accumulation and expansion of regulatory T cells, leading to the modulation of immune responses in tumor microenvironment.
Objective: To assess the effect of tumoral ASCs on the trend of regulatory T cells differentiation.
Methods: Peripheral blood naïve CD4+ T cells were co-cultured with ASCs derived from breast cancer or normal breast tissues. In separate cultures peripheral blood naïve CD4+ T cells were exposed to the culture supernatants of ASCs.
Results: Generation of CD4+CD25+Foxp3+ and CD4+CD25- Foxp3+ Treg subsets was observed after coculture of naïve CD4+ T cell with either ASCs or the related supernatant. The percentage of CD4+CD25+Foxp3+ cells increased after exposing naïve CD4+ T cells to both ASCs and their supernatants while augmentation of CD4+CD25-Foxp3+ subset mostly depended on the presence of ASCs. Similarly, upregulation of FoxP3 molecule was more significant in condition of cell to cell contact. IL-4 and IL-10 were up-regulated in the cocultured naïve CD4+ T cells after exposure to ASCs/supernatant while IFN-γ was down-regulated in the presence of ASCs.
Conclusion: Accordingly, ASC may act as one of the major players in tumor site with immunomodulatory effects, which may mostly be carried out through direct cellcell interaction.
کلیدواژه‌ها
Adipose Derived Stem Cell (ASC)؛ Breast cancer؛ Naïve CD4+ T Cell؛ Regulatory T Cell؛ Tumor Microenvironment
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