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Farid, Reza, Jabbari Azad, Farahzad, Gaffari, Javad, Rangbar, Alireza, Nikjoy, Zahra. (1383). Serum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls. سامانه مدیریت نشریات علمی, 1(1), 71-75. doi: 10.22034/iji.2004.16710
Reza Farid; Farahzad Jabbari Azad; Javad Gaffari; Alireza Rangbar; Zahra Nikjoy. "Serum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls". سامانه مدیریت نشریات علمی, 1, 1, 1383, 71-75. doi: 10.22034/iji.2004.16710
Farid, Reza, Jabbari Azad, Farahzad, Gaffari, Javad, Rangbar, Alireza, Nikjoy, Zahra. (1383). 'Serum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls', سامانه مدیریت نشریات علمی, 1(1), pp. 71-75. doi: 10.22034/iji.2004.16710
Farid, Reza, Jabbari Azad, Farahzad, Gaffari, Javad, Rangbar, Alireza, Nikjoy, Zahra. Serum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls. سامانه مدیریت نشریات علمی, 1383; 1(1): 71-75. doi: 10.22034/iji.2004.16710

Serum Level of Selenium, IL-4, IL-10 & IFN-g in Patients with Allergic Asthma, Allergic Rhinitis and Healthy Controls

Iranian Journal of Immunology
مقاله 8، دوره 1، شماره 1، شهریور 2004، صفحه 71-75    اصل مقاله (489.19 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2004.16710
نویسندگان
Reza Farid* 1؛ Farahzad Jabbari Azad1؛ Javad Gaffari1؛ Alireza Rangbar2؛ Zahra Nikjoy1
1Bu-Ali Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2Koeln Immunology Research Center, Germany
چکیده
Background: Allergic diseases have increased during the past decade worldwide. Th2 type lymphocyte response is known to play an important role in the process of allergic inflammation. IL-4, a mediator of type II cytokine response increases IgE synthesis and Interferon gamma, a cytokine of type I response interferes with IL-4 and inhibits IgE production. Selenium is an essential component of glutathione peroxides and changes in its plasma level has been proposed to be associated with allergic diseases. Materials and
Methods: This study comprised of 21 cases of allergic asthma (AA), 33 cases of allergic rhinitis (AR) whose age and sex were matched with 28 healthy controls. IL-4, IL-10, IFN-g levels were tested by ELISA assay, and serum selenium was measured by atomic absorption spectorphotometery method.
Results: Mean serum selenium level of AA and AR groups were lower than controls. Mean serum IL-4 level of AA was higher than the AR group. Mean serum IL-4 level of AA and AR group were higher than controls.
Conclusion: The results of this study indicate that low selenium level may have a role in the pathogenesis of allergic diseases.
کلیدواژه‌ها
Allergic Rhinitis؛ Eosinophilia؛ prevalence
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