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Amirzargar, Ali Akbar, Bagheri, Morteza, Ghavamzadeh, Ardeshir, Alimoghadam, Kamran, Khosravi, Farideh, Nicknam, Mohammad Hossein, Moheydin, Mandana, Ansaripour, Bita, Moradi, Batul, Nikbin, Behrouz. (1383). Th1 and Th2 Cytokine Gene Polymorphism in Iranian Patients with Chronic Myelogenous Leukemia. سامانه مدیریت نشریات علمی, 1(1), 26-33. doi: 10.22034/iji.2004.16704
Ali Akbar Amirzargar; Morteza Bagheri; Ardeshir Ghavamzadeh; Kamran Alimoghadam; Farideh Khosravi; Mohammad Hossein Nicknam; Mandana Moheydin; Bita Ansaripour; Batul Moradi; Behrouz Nikbin. "Th1 and Th2 Cytokine Gene Polymorphism in Iranian Patients with Chronic Myelogenous Leukemia". سامانه مدیریت نشریات علمی, 1, 1, 1383, 26-33. doi: 10.22034/iji.2004.16704
Amirzargar, Ali Akbar, Bagheri, Morteza, Ghavamzadeh, Ardeshir, Alimoghadam, Kamran, Khosravi, Farideh, Nicknam, Mohammad Hossein, Moheydin, Mandana, Ansaripour, Bita, Moradi, Batul, Nikbin, Behrouz. (1383). 'Th1 and Th2 Cytokine Gene Polymorphism in Iranian Patients with Chronic Myelogenous Leukemia', سامانه مدیریت نشریات علمی, 1(1), pp. 26-33. doi: 10.22034/iji.2004.16704
Amirzargar, Ali Akbar, Bagheri, Morteza, Ghavamzadeh, Ardeshir, Alimoghadam, Kamran, Khosravi, Farideh, Nicknam, Mohammad Hossein, Moheydin, Mandana, Ansaripour, Bita, Moradi, Batul, Nikbin, Behrouz. Th1 and Th2 Cytokine Gene Polymorphism in Iranian Patients with Chronic Myelogenous Leukemia. سامانه مدیریت نشریات علمی, 1383; 1(1): 26-33. doi: 10.22034/iji.2004.16704

Th1 and Th2 Cytokine Gene Polymorphism in Iranian Patients with Chronic Myelogenous Leukemia

Iranian Journal of Immunology
مقاله 2، دوره 1، شماره 1، شهریور 2004، صفحه 26-33    اصل مقاله (497.39 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2004.16704
نویسندگان
Ali Akbar Amirzargar* 1؛ Morteza Bagheri2؛ Ardeshir Ghavamzadeh3؛ Kamran Alimoghadam3؛ Farideh Khosravi1؛ Mohammad Hossein Nicknam1؛ Mandana Moheydin3؛ Bita Ansaripour1؛ Batul Moradi1؛ Behrouz Nikbin1
1Immunogenetic Lab. Dep. of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Department of Sciences, University of Khatam, Tehran, Iran
3Hematology- Oncology and BMT Research Center, Shariati Hospital, Tehran, Iran
چکیده
Background:It has been hypothesized that genetic factors other than histocompatibility disparity may play a role in predisposition to developing Chronic Myelogenous Leukemia (CML). In this regard, Th1 and Th2 cytokines and their gene polymorphism seems to be important. Overall expression and secretion of cytokines is dependent, at least in part, on genetic polymorphism (nucleotide variations) within the promoter region or other regulatory sequences of cytokine genes. The majority of polymorphisms described are single nucleotide polymorphism (SNPs). The objective of this study was to analyze the genetic profile of Th1 and Th2 cytokines in 30 Iranian patients with CML and 40 healthy subjects.
Methods: In the patients and control subjects, the allelic and genotype frequencies were determined for the cytokine genes. All typing were performed by PCR-SSP assay. Allele and genotype frequencies were calculated and compared with those of normal controls.
Results: The results showed that the most frequent alleles in our patients were TGF-b TG/TG, IL-4 T at position -1089, C at position -590, T at position -33 and IL-10 A at position -1082. Whereas the following alleles - TGF-b CG/CG and IL-10 C at position -592 – were seen in much lower frequencies.
Conclusion: In conclusion, it could be suggested that the frequency of high producing TGF-b alleles and low producing IL-4 and IL-10 alleles in the CML patients is higher than the normal subjects.
کلیدواژه‌ها
Cytokine Gene Polymorphism؛ CML
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